Sanford-Burnham collaborates with 5 Florida-based research organizations

Public release date: 2-Apr-2013
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Contact: Deborah Robison
drobison@sanfordburnham.org
407-795-2073
Sanford-Burnham Medical Research Institute

The collaborations are enabled by the Florida Translational Research Program, which provides Florida-based scientists with access to Sanford-Burnham's drug discovery technology and expertise.

ORLANDO, Fla., April 2, 2013Sanford-Burnham Medical Research Institute at Lake Nona (Sanford-Burnham) announced the selection of the first five research organizations that will participate in the Florida Translational Research Program (FTRP) to advance drug discovery in the state. The projects focus on cancer, diabetes, and obesity, and are led by scientists from the University of Central Florida, the University of Florida, the University of Miami, Scripps Florida, and Sanford-Burnham. The Program provides Florida-based scientists with access to drug discovery expertise and state-of-the-art infrastructure at Sanford-Burnham.

"We fielded approximately 50 specific inquiries for the program and received a total of 15 valid applications for five project slots," said Layton Smith, Ph.D., director of Drug Discovery Florida at Sanford-Burnham, who oversees the program. "We selected these projects based on scientific merit, technical feasibility, and potential for commercialization. Work on the first collaboration began in February and we expect to complete all projects by the end of the year."

Toward new cancer therapeutics

Three of the projects focus on discovering new treatments for cancer and other tumors. Claes Wahlestedt, M.D., Ph.D., and his team at the University of Miami are trying to find chemical compounds that stop MLL3, a protein that plays a central role in the development of several leukemias, as well as breast and colon cancers. Researchers led by Daiqing Liao, Ph.D., at the University of Florida have shown that a novel drug target for cancer, acetyltransferase p300, is a master regulator of cancer-cell survival. Novel inhibitors of p300 are thus expected to prevent the development of tumors in a variety of cancers. Cristina Fernandez-Valle, Ph.D., at the University of Central Florida and her team seek compounds that block the protein merlin, which has a similar function as p300.

While the research focus of each project varies greatly, all participating scientists agree that having access to state-of-the-art screening technology enhances their ability to do research. "The immediate and potential long-term impact of this funding on my research cannot be overstated," said UCF professor and research scientist Fernandez-Valle. "There is currently no drug treatment for neurofibromatosis, a devastating tumor syndrome diagnosed in children and young adults. The results of this project and the partnership with Sanford-Burnham are critical for us to successfully compete for the continuously diminishing federal funds that we need to eventually develop an effective drug therapy for neurofibromatosis."

On the road to treating diabetes and obesity

The other two projects represent the first steps in the discovery of new medicines to treat diabetes and obesity. Patricia McDonald, Ph.D., at Scripps Florida will collaborate with Sanford-Burnham to identify molecules that block the function of a protein called GPR21, which is known to reduce the effects of insulin on the body. Fraydoon Rastinejad, Ph.D., and his lab at Sanford-Burnham seek to block the action of two other proteins that control metabolism and the expansion of fat cells, Rev-Erb? and Rev-Erb?.

The Florida Department of Health and Sanford-Burnham established the FTRP as a competitive grant program that provides funding for collaborative drug discovery projects. The overall goal of the program is to translate research discoveries made in Florida laboratories into the medicines of tomorrow.

"As a native Floridian, I am extremely proud to see the first FTRP projects come to life. There is no doubt we have the talent here in Florida to develop the medicines of tomorrow. Through the FTRP collaborations, we have the opportunity to match this talent with our infrastructure and technology platforms at Sanford-Burnham," says Smith.

This first year of the FTRP is a pilot phase with five project slots that were available; the number of projects is expected to increase next year. Applications were invited from investigators who had already developed innovative assays for use both in basic research and in therapeutic development, and who were interested in having their assay screened using Sanford-Burnham's small-molecule library. In the future, the program will accept proposals for more comprehensive projects that may have a chemical component, not yet be ready for high-throughput screening, or require assay development services from Sanford-Burnham.

###

About the Florida Translational Research Program

The purpose of the Florida Translational Research Program is to produce a pipeline of potential new medicines based on laboratory research discoveries. The program provides Florida-based scientists with access to experienced professionals and advanced technologies to facilitate an interdisciplinary, collaborative approach to developing new treatments for today's most challenging and unmet medical needs. The program is funded by the State of Florida through the Florida Department of Health and is administered by Sanford-Burnham Medical Research Institute at Lake Nona. To learn more about the Program, please visit sanfordburnham.org/ftrp.

About Sanford-Burnham Medical Research Institute

Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham takes a collaborative approach to medical research with major programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is recognized for its National Cancer Institute-designated Cancer Center and expertise in drug discovery technologies. Sanford-Burnham is a nonprofit, independent institute that employs 1,200 scientists and staff in San Diego (La Jolla), California, and Orlando (Lake Nona), Florida. For more information, visit us at sanfordburnham.org.

---

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 2-Apr-2013
[ | E-mail | Share ]

Contact: Deborah Robison
drobison@sanfordburnham.org
407-795-2073
Sanford-Burnham Medical Research Institute

The collaborations are enabled by the Florida Translational Research Program, which provides Florida-based scientists with access to Sanford-Burnham's drug discovery technology and expertise.

ORLANDO, Fla., April 2, 2013Sanford-Burnham Medical Research Institute at Lake Nona (Sanford-Burnham) announced the selection of the first five research organizations that will participate in the Florida Translational Research Program (FTRP) to advance drug discovery in the state. The projects focus on cancer, diabetes, and obesity, and are led by scientists from the University of Central Florida, the University of Florida, the University of Miami, Scripps Florida, and Sanford-Burnham. The Program provides Florida-based scientists with access to drug discovery expertise and state-of-the-art infrastructure at Sanford-Burnham.

"We fielded approximately 50 specific inquiries for the program and received a total of 15 valid applications for five project slots," said Layton Smith, Ph.D., director of Drug Discovery Florida at Sanford-Burnham, who oversees the program. "We selected these projects based on scientific merit, technical feasibility, and potential for commercialization. Work on the first collaboration began in February and we expect to complete all projects by the end of the year."

Toward new cancer therapeutics

Three of the projects focus on discovering new treatments for cancer and other tumors. Claes Wahlestedt, M.D., Ph.D., and his team at the University of Miami are trying to find chemical compounds that stop MLL3, a protein that plays a central role in the development of several leukemias, as well as breast and colon cancers. Researchers led by Daiqing Liao, Ph.D., at the University of Florida have shown that a novel drug target for cancer, acetyltransferase p300, is a master regulator of cancer-cell survival. Novel inhibitors of p300 are thus expected to prevent the development of tumors in a variety of cancers. Cristina Fernandez-Valle, Ph.D., at the University of Central Florida and her team seek compounds that block the protein merlin, which has a similar function as p300.

While the research focus of each project varies greatly, all participating scientists agree that having access to state-of-the-art screening technology enhances their ability to do research. "The immediate and potential long-term impact of this funding on my research cannot be overstated," said UCF professor and research scientist Fernandez-Valle. "There is currently no drug treatment for neurofibromatosis, a devastating tumor syndrome diagnosed in children and young adults. The results of this project and the partnership with Sanford-Burnham are critical for us to successfully compete for the continuously diminishing federal funds that we need to eventually develop an effective drug therapy for neurofibromatosis."

On the road to treating diabetes and obesity

The other two projects represent the first steps in the discovery of new medicines to treat diabetes and obesity. Patricia McDonald, Ph.D., at Scripps Florida will collaborate with Sanford-Burnham to identify molecules that block the function of a protein called GPR21, which is known to reduce the effects of insulin on the body. Fraydoon Rastinejad, Ph.D., and his lab at Sanford-Burnham seek to block the action of two other proteins that control metabolism and the expansion of fat cells, Rev-Erb? and Rev-Erb?.

The Florida Department of Health and Sanford-Burnham established the FTRP as a competitive grant program that provides funding for collaborative drug discovery projects. The overall goal of the program is to translate research discoveries made in Florida laboratories into the medicines of tomorrow.

"As a native Floridian, I am extremely proud to see the first FTRP projects come to life. There is no doubt we have the talent here in Florida to develop the medicines of tomorrow. Through the FTRP collaborations, we have the opportunity to match this talent with our infrastructure and technology platforms at Sanford-Burnham," says Smith.

This first year of the FTRP is a pilot phase with five project slots that were available; the number of projects is expected to increase next year. Applications were invited from investigators who had already developed innovative assays for use both in basic research and in therapeutic development, and who were interested in having their assay screened using Sanford-Burnham's small-molecule library. In the future, the program will accept proposals for more comprehensive projects that may have a chemical component, not yet be ready for high-throughput screening, or require assay development services from Sanford-Burnham.

###

About the Florida Translational Research Program

The purpose of the Florida Translational Research Program is to produce a pipeline of potential new medicines based on laboratory research discoveries. The program provides Florida-based scientists with access to experienced professionals and advanced technologies to facilitate an interdisciplinary, collaborative approach to developing new treatments for today's most challenging and unmet medical needs. The program is funded by the State of Florida through the Florida Department of Health and is administered by Sanford-Burnham Medical Research Institute at Lake Nona. To learn more about the Program, please visit sanfordburnham.org/ftrp.

About Sanford-Burnham Medical Research Institute

Sanford-Burnham Medical Research Institute is dedicated to discovering the fundamental molecular causes of disease and devising the innovative therapies of tomorrow. Sanford-Burnham takes a collaborative approach to medical research with major programs in cancer, neurodegeneration, diabetes, and infectious, inflammatory, and childhood diseases. The Institute is recognized for its National Cancer Institute-designated Cancer Center and expertise in drug discovery technologies. Sanford-Burnham is a nonprofit, independent institute that employs 1,200 scientists and staff in San Diego (La Jolla), California, and Orlando (Lake Nona), Florida. For more information, visit us at sanfordburnham.org.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/smri-scw040113.php

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Mal's Miles: Spring Break with Stephanie @ Seven Days and Sunny

1. Stop Talking! If he calls, texts, bbm?s, or stops by your

house you don?t respond and you delete!

If the relationship is dead you bury it. You don?t make friends with it and don?t talk to it. This is the hardest rule to follow but it has the quickest results.

2. Complete the following questionnaire and keep it to one page
?????1. List 5 things about HIM that you loved
?????2. List 5 events?which happened in the relationship that you loved
?????3. List 5 crappy things about HIM that you couldn?t stand
?????4. List 5 crappy things he DID to you
?????5. List your top 3 perfect girlfriend behaviors
?????6. List your top 3 areas of self-improvement
?????7. List 3 things you want in a husband based on your answers
?????8. List the top 3 things you?ll do for/with your future husband

Now, Print it and put it in your journal or someplace with easy access but that is out of daily sight.

3. Purge
???? 1. Delete From/Sent e-mails
???? 2. Trash photos. Yep, its awful but future boyfriend doesn?t want to see them either.
???? 3. Delete texts
???? 4. Unfriend. This is actually painful and you will feel regret but you must do it.
???? 5. Delete Facebook posts/pictures and block him before he blocks you
???? 6. Delete his phone number ? Get rid of it so your friends don?t have to lock?your phone in their car when you?re at the bars.

4. The Stop List
????????? 1. Stop fantasizing he changes his mind and begs you to come back
????????? 2. Stop internet stalking
????????? 3. Stop secretly trying to will his death
????????? 4. Stop talking to your family and friends about him. Even if you have to stop saying his name all together.

5. The Start List
????????? 1. ?Find new BF or at least a new crush
????????? 2. Search Match.com for someone better looking and more successful.?? You don?t have to reach out but it?s good to take the focus off him and start looking at other men
????????? 3. Find alternate ?thinking of him activity?
?????????????????? a.?ie go for walk or do free French tutorials online
????????? 4. Start fantasizing about someone else. I personally use Chris Pine?? because Chris Pine is sexy.

6. Focus on yourself. Read any self-improvement books that appeal to you. I prefer the following subjects:
????????? 1. Fashion
????????? 2. Makeup
????????? 3. Fitness
????????? 4. Organization
????????? 5. Money
????????? 6. Etiquette

7. Write and repeat an affirmation for tough moments.
????????? 1. I can do better.
????????? 2. He is gay.

8. Clean your entire house, car and office. You need to bring order to other areas of your life.

9. Work longer hours. Having a solid career is key to a fulfilling life. Spend some extra time at work just organizing and cleaning up. . Get a few projects in BEFORE deadline. People will notice and it will help build you up.

10. Journal. Nobody said this was easy. In fact, it will be so hard you might beg for him back, you might drive by his house or Google him a hundred times a day. Write it out in your journal and remember that you want to like yourself again and not this weepy, obsessive, puddle of mush you?ve become.

If you fail, and you will, just get right back up. GET MAD! You?re better than some crazy ex-girlfriend who spends her days, weeks, or months getting over a guy when there are a million of them out there. So, put on your big girl panties and buck up because the more time you waste the more pretty you waste.

Source: http://www.malsmiles.com/2013/04/spring-break-with-stephanie-seven-days.html

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Saudi Maaden shuts ammonia plant for two weeks of repairs

DUBAI, April 2 (Reuters) - Maaden Phosphate Company (MPC)

shut its ammonia plant at Ras Al Khair on Monday for unscheduled

repairs which are expected to take about two weeks, Saudi

Arabian Mining Company (Maaden) said on Tuesday.

Maaden said in a statement to the Saudi stock market that

the shutdown for "technical repairs" would have no impact on its

ability to meet supply obligations to customers.

The plant produces ammonia used to make Diammonium Phosphate

(DAP) at the complex, but the DAP plant will continue to produce

normally using ammonia stocks, it said.

MPC is co-owned by Maaden (70 percent) and Saudi Basic

Industries Corporation (30 percent).

(Reporting by Daniel Fineren; Editing by Mark Potter)

Source: http://news.yahoo.com/saudi-maaden-shuts-ammonia-plant-two-weeks-repairs-054808136--business.html

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In Nelson, Ga., you now have to own a gun

NELSON, Ga. (AP) ? Backers of a newly adopted ordinance requiring gun ownership in a small north Georgia town acknowledge they were largely seeking to make a point about gun rights.

The ordinance in the city of Nelson ? population 1,300 ? was approved Monday night and goes into effect in 10 days. However, it contains no penalties and exempts anyone who objects, convicted felons and those with certain mental and physical disabilities.

City Councilman Duane Cronic, who sponsored the measure, said he knows the ordinance won't be enforced but he still believes it will make the town safer.

"I likened it to a security sign that people put up in their front yards. Some people have security systems, some people don't, but they put those signs up," he said. "I really felt like this ordinance was a security sign for our city."

Another purpose, according to the city council's agenda, is "opposition of any future attempt by the federal government to confiscate personal firearms."

Council members in Nelson, a small city located 50 miles north of Atlanta, voted unanimously to approve the Family Protection Ordinance. The measure requires every head of household to own a gun and ammunition to "provide for the emergency management of the city" and to "provide for and protect the safety, security and general welfare of the city and its inhabitants."

Nelson resident Lamar Kellett was one of five people who spoke during a public comment period Monday night and one of two who opposed the ordinance. Among his many objections, he said it dilutes the city's laws to pass measures that aren't intended to be enforced.

"Does this mean now 55 miles an hour speed limit means 65, 80, whatever you choose? There's not a whole lot of difference. A law's a law," he said.

Kellett also said the ordinance will have no effect, that it won't encourage people like him who don't want a gun to go out and buy one.

The proposal illustrates how the response to the massacre at an elementary school in Newtown, Conn., varies widely in different parts of the country.

While lawmakers in generally more liberal states with large urban centers like New York and California have moved to tighten gun control laws, more conservative, rural areas in the American heartland have been going in the opposite direction.

Among the other efforts to broaden gun rights that have surfaced since the Newtown killings:

? Earlier Monday, lawmakers in Oklahoma scuttled a bill that would have allowed public school districts to decide whether to let teachers be armed.

? Spring City, Utah, passed an ordinance this year recommending that residents keep firearms, softening an initial proposal that aimed to require it.

? Residents of tiny Byron, Maine, rejected a proposal last month that would have required a gun in every home. Even some who initially supported the measure said it should have recommended gun ownership instead of requiring it, and worried that the proposal had made the community a laughingstock. Selectmen of another Maine town, Sabbatus, threw out a similar measure. The state's attorney general said state law prevents municipalities from passing their own firearms laws anyway.

? Lawmakers in about two dozen states have considered making it easier for school employees or volunteers to carry guns on campus. South Dakota passed such a measure last month. Individual communities from New Jersey to Colorado have voted to allow administrators or teachers to carry guns in school.

Located in the Appalachian foothills, Nelson is a tiny, hilly town with narrow, twisting roads. It's a place where most people know one another and leave their doors unlocked.

It used to be a major source of marble, with the local marble company employing many in town. But that industry is mostly gone now, Mayor Mike Haviland said. There are no retail stores in town anymore, and just about everyone leaves town for work now, making it a bedroom community for Atlanta, he said.

The mayor said he never dreamed his small city would be the focus of national and international media attention, but he understands it.

"It bumps up against the national issues on guns," he said.

Police Chief Heath Mitchell noted that the city doesn't have police officers who work 24 hours a day and is far from the two sheriff's offices that might send deputies in case of trouble, so response times to emergency calls can be long. Having a gun would help residents take their protection into their own hands, he said.

But the chief ? the town's sole police officer ? acknowledged the crime rate is very low. He mostly sees minor property thefts and a burglary every few months. The most recent homicide was more than five years ago, he said.

The ordinance is modeled after a similar one adopted in 1982 by Kennesaw, an Atlanta suburb. City officials there worried at the time that growth in Atlanta might bring crime to the community, which now has about 30,000 residents. Kennesaw police have acknowledged that their ordinance is difficult to enforce, and they haven't made any attempt to do so.

Leroy Blackwell, 82, has lived in Nelson for about 50 years and owns a hunting rifle he keeps in a closet. He said before the council's decision that he would support the ordinance even if it didn't have exemptions, but he would have preferred it to be voluntary.

"Really, I think it would be more fair to put it to a vote" so everybody could have a say, he said.

Source: http://news.yahoo.com/ga-city-council-votes-require-gun-ownership-003042709.html

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Windows Phone sees big gains at the expense of BlackBerry and Symbian

Alright, so Microsoft is in no danger of toppling iOS or Android anytime soon. But the analytics firm Kantar has seen significant growth for Windows Phone, largely at the expense of BlackBerry. In practically every major market WP8 has started to chip away at its competitors, growing from 6.2 percent to 6.7 percent share in the UK in just one month. Twelve months ago it was at only three percent in the country. The most dramatic ascent has taken place in Italy where it accounted for just 5.4 percent of handsets sold in February of 2012, and now makes up 13.1 percent of sales. Even in the US Windows Phone is seeing steady, if hardly eye-popping growth.

Symbian and BlackBerry are obviously the biggest losers. In Mexico, both platforms have seen double digit drops in their share of sales over the last year. While in the UK, the company formerly known as RIM has gone from a seemingly secure third place with 16.8 percent of the market to a quickly fading fourth with 5.1 percent is just 12 months. Meanwhile, Apple is sitting pretty with hardly a change to its position and Android continues its juggernaut-like assault on all markets. To see the complete global figures check out the images after the break.

Filed under: Cellphones, Mobile

Comments

Via: WMPoweruser

Source: Kantar 1, 2

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/gYMVzmf5R2I/

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South Florida girl, 4, shot dead in car

By Gilma Avalos and Brian Hamacher, NBCMiami.com

Miami-Dade Police are investigating after a 4-year-old girl died after she was shot inside a car Saturday night.

The shooting happened just after 6 p.m. in the 12000 block of Northwest 20th Avenue, as the girl was sitting in a parked Mercedes Benz with several other small children, police said.

Somehow the girl, later identified as Rahquel Carr, was shot in her upper body. Carr was taken to Ryder Trauma Center where she later died, police said.

Related: 3-Year-Old Girl Pulled From Pool at Miami Home, Rushed to Hospital

Police said it's unclear if one of the other children in the car was responsible for the shooting. An adult was nearby when the shooting happened, police said.

Under Florida law, a firearm must be securely encased when in a vehicle. It is unclear where the firearm was located at the time of the shooting.

"We will be looking at who this firearm belonged to, were the firearm was in the vehicle at the time, along with who was present when the gun was fired," said Miami-Dade Police spokesman Det. Roy Rutland.

Related: Miami Beach Holds First Ever Gun Buyback

No arrests have been made. Children were witnesses to the shooting and Miami-Dade Police will be forced to interview them, as well as many family members, Rutland said.

"There's a lot of speculation right now as to who had that firearm at the time, but we're not in the business of speculating, we're in the business of facts," Rutland said.

Distraught family members and friends arrived to the home Saturday night to give them support.

"Someone called my daughter, and told her she got shot," said Sonia Wheelers, who said she is like a grandmother to the child. "It's horrible, it's sad."

The shooting is still being investigated and the Miami-Dade County Medical Examiner Department will be conducting an autopsy on the child, police said.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2a2f5161/l/0Lusnews0Bnbcnews0N0C0Inews0C20A130C0A30C310C175396960Esouth0Eflorida0Egirl0E40Eshot0Edead0Ein0Ecar0Dlite/story01.htm

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Mike McLelland, Kaufman County District Attorney, Found Dead With Wife In Texas Home

KAUFMAN, Texas ? A sheriff's deputy says authorities are investigating the deaths of a North Texas county district attorney and his wife who were found dead in a home.

Kaufman County Sheriff's Office spokesman Lt. Justin Lewis said Saturday that the county District Attorney, Mike McLelland, and his wife, Cynthia, were found dead in a home in an unincorporated part of the county. Authorities have blocked off the street where the couple's last known address is located.

Lewis said he couldn't discuss the investigation in further detail, including how the couple died and whether investigators believe their deaths are linked to the Jan. 31 slaying of an assistant Kaufman County district attorney, Mark Hasse.

The Dallas Morning News reports that Kaufman Police Chief Chris Albaugh confirmed the couple was shot at their home.

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Source: http://www.huffingtonpost.com/2013/03/30/mike-mclelland-found-dead_n_2986663.html

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